Table 1.

Expression of proinflammatory cytokines in adult and old mice

Cytokine	Adult (fold change ± SD)	Old (fold change ± SD)
IL-1β	1.45 ± 0.21	3.28 ± 0.83 (P < 0.01)
IL-6	1.83 ± 0.2 (P < 0.01)	2.34 ± 0.13 (P < 0.001)
TNF-α	0.96 ± 0.1	3.07 ± 0.75 (P < 0.01)

Young (aged 6–8 weeks, n = 3), adult (aged 7–8 months, n = 4), and old (aged 19 months, n = 6) C57BL6 mice were analyzed for IL-1β, IL-6, and TNFα gene expression in the brain as described in Experimental procedures. Data are presented as fold change compared with young mice. Data were analyzed by a one-way Tukey’s ANOVA.