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. 2014 May 30;13(4):744–754. doi: 10.1111/acel.12229

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© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The Wnt signaling defect in aged human hematopoietic stem cells (HSCs) is present in the early T-progenitor subset. Young (solid line) and aged (dotted line) HSCs were co-cultured with OP9-DL1 stromal layers and examined for the expression of (A) CD34, (B) CD34 and β-catenin, (C) CD34 and CD7, (D) CD7, (E) CD7 and β-catenin, and (F) CD14 and CD7, during the first month of differentiation. β-Catenin is expressed by cells derived from both young and aged HSCs that possess characteristics of T-cell progenitors, but aged HSCs are initially fewer in proportion, limited in β-catenin expression, and exhibit delayed differentiation. bCat: β-catenin. *P < 0.05 (n = 3), **P < 0.01 (n = 3).