Table 1.
Clinical biochemistry and echocardiographic parameters of the 3 study groups
| Variable | AH (n = 30) | CHF (n = 24) | CTL (n = 25) | Statistical analysis, p values |
|||
|---|---|---|---|---|---|---|---|
| Kruskall-Wallis | Mann-Whitney |
||||||
| AH vs. CHF | CHF vs. CTL | AH vs. CTL | |||||
| Age, years | 59 (54–66) | 70 (66–76) | 56 (49–62) | ||||
| Male/female | 28/2 | 16/8 | 16/9 | ||||
| b2M, ng/ml | 1,096.0 (934.5–1,229.0) | 2,167.0 (1,498–2,703) | 1,131.0 (1,050–1,329) | <0.0001 | <0.0001 | <0.0001 | n.s. |
| TIMP1, ng/ml | 232.1 (187.2–274.7) | 278.8 (214.6–348.1) | 220.8 (192.5–280.5) | 0.0407 | 0.0243 | 0.0319 | n.s. |
| NT-proBNP, pg/ml | 32.0 (21.5–44.5) | 616.0 (135–1,421) | 33.0 (21.5–80.0) | <0.0001 | <0.0001 | <0.0001 | n.s. |
| GFR, ml/min/1.73 m2 | 106.5 (96.0–116.5) | 77.5 (58.7–93.5) | 109.0 (98.0–116.5) | <0.0001 | <0.0001 | <0.0001 | n.s. |
| CRP, mg/dl | 0.095 (0.04–0.2175) | 0.26 (0.1–0.66) | 0.11 (0.04–0.55) | 0.0067 | 0.0010 | n.s. | n.s. |
| LV mass index, g/m2 | 121.0 (105.0–135.5) | 141.7 (119.9–183.5) | 83.3 (78.2–102.0) | <0.0001 | 0.0252 | <0.0001 | <0.0001 |
| Parietal thickness, cm | 1.07 (1.0–1.16) | 1.1 (1.0–1.2) | 1.0 (0.9–1.0) | 0.0026 | n.s. | 0.0004 | 0.0081 |
| Septal thickness, cm | 1.21 (1.13–1.27) | 1.275 (1.163–1.300) | 1.0 (1.0–1.1) | <0.0001 | n.s. | <0.0001 | <0.0001 |
| LVEDD, cm | 5.3 (5.0–5.55) | 5.4 (5.025–5.775) | 5.0 (4.7–5.0) | 0.0003 | n.s. | 0.0002 | 0.0013 |
| EF% | 62 (58–63) | 39 (30–49) | 65 (65–66) | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
For all descriptive values, medians with 25th–75th percentiles in parentheses are reported. n.s. = Not significant; LVEDD = LV telediastolic diameter.