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. 2015 Feb 13;5:31. doi: 10.3389/fonc.2015.00031

Figure 1.

Figure 1

A schematic diagram of the signaling and molecular features of melanoma phenotype switching. The EMT-like phenotype switching confers melanoma invasive functions. The EMT-associated signaling in melanoma is also implicated in conferring resistance to BRAF inhibition therapies in BRAF-mutant metastatic melanoma.