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. 2015 Feb 13;9:39. doi: 10.3389/fnins.2015.00039

Figure 1.

Figure 1

Modulation of METH-induced locomotor activity and sensitization by TAAR1. (A) Chronic exposure to methamphetamine gradually increased locomotor activity. Low and moderate doses of RO5203648 attenuated METH-induced locomotor activity and blocked the progressive increment induced by repeated exposure to METH. (B) Following withdrawal from chronic METH exposure, a challenge with a low dose of METH produced sensitized locomotor responsiveness. The long-term expression of locomotor sensitization was prevented in rats that had received concurrent treatment with RO5203648 (at either low or moderate doses) and METH. Treatment with the high dose of RO5203648 alone during the sensitization phase enhanced the subsequent long-term response to METH. (C) METH produced robust increases in locomotor activity compared with control treatment in a 3-h activity test. RO5203648 produced an early attenuation and a late potentiation of METH-stimulated locomotor activity. φp < 0.01, different from acute METH (day 1); #p < 0.01, different from chronic METH (day 7), *p < 0.01 different from METH (after chronic control treatment), ϕp < 0.01 different from METH (after chronic METH exposure). RO = RO5203648, MA = methamphetamine.