. 2015 Feb 4;10:1109–1118. doi: 10.2147/IJN.S72835

Table 1.

Central composite design and response variables for processing of astaxanthin nanodispersions

Sample number	Time (minutes)	Speed ×1,000 (rpm)	Particle size^* (nm)	PDI^*	Astaxanthin loss^* (% w/w)
1	10.0	5.0	92.0±2.10^g	0.275±0.0018^e	35.3±0.77^d
2	10.0	1.0	133.4±0.18^c	0.217±0.0080^g	15.3±2.60^g
3	10.0	9.0	112.3±1.68^e	0.507±0.0026^b	58.9±3.30^c
4	10.0	5.0	91.2±0.92^g	0.276±0.0065^e	35.0±0.02^d
5	20.0	5.0	135.1±0.98^b	0.467±0.0019^c	65.8±1.90^b
6	0.5	5.0	106.2±1.87^f	0.434±0.0021^d	8.9±0.00^h
7	10.0	5.0	91.3±1.55^g	0.276±0.0557^e	35.7±0.45^d
8	17.1	7.8	82.7±2.00ⁱ	0.602±0.0077^a	70.2±0.01^a
9	10.0	5.0	91.4±0.86^g	0.275±0.0025^e	35.5±0.44^d
10	2.9	7.8	96.2±1.02^h	0.434±0.0010^d	28.4±0.02^f
11	17.1	2.2	146.5±0.54^a	0.240±0.0094^f	29.8±1.00^e
12	10.0	5.0	91.4±0.42^g	0.276±0.0101^e	35.8±0.80^d
13	10.0	5.0	91.2±1.05^g	0.276±0.0051^e	35.1±0.12^d
14	2.9	2.2	116.9±1.51^d	0.239±0.0062^f	7.3±1.08ⁱ

Notes:

Experimental values of responses. Values are shown as the mean ± standard deviation (n=3).

^a–i

Different letters show statistically significant differences (P<0.05) between response values in which the comparison tests were performed between similar responses.

Abbreviation: PDI, polydispersity index.