Figure 5.
Histological analysis of the effect of BMP-7 nanoreservoirs in vivo on bone tissue regeneration.
Notes: Histological analysis of in vivo bone induction onto functionalized PCL scaffold (NR4) compared to bare PCL (NF) scaffold after 30 days of calvaria implantation in mice. Mallory coloration was used in order to identify mineralized extracellular matrix (pink) and cell nuclei (blue). The square area in the drawn scheme represents the histological section inside the mouse calvaria defects.
Abbreviations: HB, host bone; NF, not functionalized; NR4, functionalized with (chitosan/BMP-7)4 nanocontainers; PCL, poly(ε-caprolactone).