Figure 3.

Possible mechanism of PPARα and NFκB regulation in platelets. Platelet activation leads to NFκB phosphorylation and activation, which potentiates activation signals. PKCα is also phosphorylated and activated in response to stimulation. This may lead to an interaction between PPARα and PKCα, leading to increased activation. Treatment with PPARα ligands prevents PPARα binding to PKCα, but instead enhances its interaction with NFκB, thus functionally sequestering PPARα and NFκB from participating in activation signaling.