Table 1.
Identified transcription factors in platelets.
| Transcription factor | Activation of transcription factor | Agonist-induced activation |
|---|---|---|
| p65 | Phosphorylation | ↑Aggregation, spreading, clot retraction, GPIBα shedding |
| PPARγ | Ligand binding (15d-PGJ2, TZDs) | ↓Aggregation, CD40L, TXB2, P-selectin |
| Phosphorylation | ↑Collagen-induced activation and granule secretion | |
| PPARβ/δ | Ligand binding (GW501516, PGI2) | ↓Aggregation |
| PPARα | Ligand binding (fenofibrate) | ↓Aggregation |
| Phosphorylation | ↑Activation | |
| LXRβ | Ligand binding | ↓Collagen-induced aggregation |
| RXRα | Ligand binding (9cRA) | ↓Activation |
| GR | Ligand binding (prednisolone) | ↓Activation |
| Ligand binding (dexamethasone) | Unknown | |
| AHR | Ligand binding | ↑Activation |
| STAT3 | Phosphorylation | ↑Aggregation, P-selectin, thrombosis |