Table 2.
Identified and possible interactions of transcription factors in platelets with other proteins.
| Transcription factor | Known protein interaction |
Possible protein interactions |
||
|---|---|---|---|---|
| Binding partners | Outcome | Binding partners | Outcome | |
| PPARγ | Syk, LAT | Platelet activation | NFκB (p65) | Inhibit NFκB activity → anti-platelet effect |
| p-ERK, p-p38 | Granule secretion | MEK/ERK | Increased activation | |
| PKCα | Reduce PKCα activation | |||
| PPARβ/δ | PKCα | Dampen platelet adhesion | – | – |
| PPARα | NFkB | Inhibit NFκB activity → anti-platelet effect | PKCα | Increased activation |
| LXRβ | Syk, LAT | Dampen platelet activation | PPARγ | Unknown |
| RXRα | PPARγ | Unknown | Gq | Decreased activation |
| GR | HSP90 | Unknown | – | – |
| Mineralocorticoid Receptor | Unknown | – | – | |
| AHR | – | – | NFκB (p65) | Unknown |