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. 2015 Feb 13;5:284. doi: 10.3389/fphar.2014.00284

Figure 6.

Figure 6

Selective In vivo interaction of C. aurantium extract with mGluR. Fish were allowed 1 h absorption of various concentrations of selective mGluR antagonist PHCC(mGluRI), EGLU(mGluRII), CPPG(mGLURII) followed by 1 h absorption on C. aurantium extract 28 mg/mL prior exposure to PTZ 3 mg/mL. (A) PHCC at 0.5 μM significantly reduced seizure latency by 32% and at 1.2 μM significantly increased seizure latency by 38% when compared to C. aurantium alone. (B) EGLU 3 and 6.4 μM, significantly reduced the increase in seizure latency caused by treatment with C. aurantium extract by 33 and 29%, respectively. (C) mGluR III antagonist CPPG had no effect on the changes in seizure latency caused by exposure to C. aurantium extract. Results are shown as average ± SEM of at least three experiments, n > 12. **** vs. Naive P < 0.0001, # vs. C. aurantium 28 mg/ml P < 0.05; ##P < 0.01.