Table 2.
Changes in glucose metabolism, lipids and other metabolic parameters over 8-week study period
| Aripiprazole (N=16) | Placebo (N=14) | p | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| Baseline | Week 8 change | Baseline | Week 8 change | ||||||
|
|
|||||||||
| Variable | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Fasting plasma glucose (mg/dL) | 112.6 | 26.5 | 0.9 | 15.6 | 97.1 | 18.4 | 7.5 | 26.4 | 0.206 |
| Fasting serum insulin (μIU/mL) | 12.7 | 7.7 | −1.5 | 8.6 | 11.1 | 7.7 | 3.5 | 10.8 | 0.195 |
| HOMA-IR | 3.8 | 3.4 | −0.7 | 2.8 | 2.9 | 2.5 | 2.6 | 5.6 | 0.065 |
| HbA1c (%) | 6.70 | 1.74 | −0.32 | 0.63 | 6.08 | 0.51 | 0.01 | 0.34 | 0.381 |
| SI (× 10 – 4 min−1) | 4.2 | 3.9 | 0.6 | 3.8 | 4.2 | 3.9 | 0.65 | 1.9 | 0.082 |
| SG (min−1) | 0.012 | 0.006 | 0.003 | 0.006 | 0.013 | 0.007 | −0.005 | 0.007 | 0.010 |
| AIRG (AUC, 0–10) (μU/mL per 10 min) | 240.7 | 251.2 | −64.1 | 131.8 | 292.0 | 362.0 | −78.1 | 134 | 0.737 |
| DI | 833 | 1,246 | −296 | 1,243 | 756 | 578 | −222 | 651 | 0.579 |
| Total cholesterol (mg/dL) | 181.0 | 46.4 | −15.3 | 33.3 | 179.1 | 23.7 | 5.6 | 34.0 | 0.125 |
| Direct LDL (mg/dL) | 101.0 | 32.5 | −15.1 | 19.8 | 101.6 | 29.2 | 4.4 | 22.5 | 0.019 |
| HDL (mg/dL) | 39.4 | 9.2 | −0.4 | 5.6 | 39.3 | 8.9 | −2.7 | 6.2 | 0.321 |
| Triglycerides (mg/dL) | 207.9 | 127.6 | −5.9 | 75.1 | 222.1 | 100.6 | −7.3 | 100.3 | 0.982 |
| LDL particle number (nmol/L) | 1,610 | 763 | −376 | 632 | 1,628 | 252 | −36 | 301 | 0.035 |
| LDL particle size (nm) | 21.02 | 0.98 | −0.19 | 0.80 | 20.33 | 0.52 | 0.41 | 0.26 | 0.271 |
| Small LDL particle number (nmol/L) | 1,065 | 772 | −246 | 675 | 1,213 | 266 | −148 | 316 | 0.241 |
| Large HDL particle number (nmol/L) | 6.12 | 3.93 | 0.66 | 2.23 | 5.13 | 3.16 | −0.36 | 1.77 | 0.281 |
| Large VLDL particle number (nmol/L) | 5.10 | 4.34 | −1.62 | 4.84 | 8.66 | 8.39 | −2.58 | 8.14 | 0.534 |
Week 8 change equals week 8 value minus baseline value.
P values were based on ANCOVA comparing between group differences in week 8 changes controlling for baseline values
HOMA-IR, homeostasis model of assessment of insulin resistance; HbA1c, hemoglobin A1c; SI, insulin sensitivity index; SG, glucose effectiveness; AIRG, acute insulin response to glucose; DI, disposition index; HDL, high-density lipoprotein; LDL, low-density lipoprotein; VLDL, very-low-density lipoprotein