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. Author manuscript; available in PMC: 2015 Feb 13.
Published in final edited form as: Prog Mol Biol Transl Sci. 2010;95:237–298. doi: 10.1016/B978-0-12-385071-3.00009-5

Figure 11. Imaging of UV-induced apoptosis in transgenic animals.

Figure 11

Transgenic mice were shaved and UVB-irradiated (b) or mock irradiated (a). The irradiated area is outlined as a red square. After irradiation, mice were injected with the fluorescent substrate DDAOG (9H-{1,3-dichloro-9,9-dimethylacridin-2-one-7-yl} β-D-galactopyranoside) and imaged using a Xenogen IVIS system. As compared with the control animals, the UVB-treated animals showed a significant fluorescent signal 24 hours after radiation. (c) Control animals (open bar) showed an approximately 10% change in fluorescence, whereas UV-irradiated animals (solid bar) had an 80% mean increase in fluorescence activity. Error bars represent ± SD, n = 5 animals per group. (From [48], with permission).