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. Author manuscript; available in PMC: 2015 Feb 13.
Published in final edited form as: Prog Mol Biol Transl Sci. 2010;95:237–298. doi: 10.1016/B978-0-12-385071-3.00009-5

Figure 4. Schematic diagram illustrating the NLG reporter design.

Figure 4

A, the ER translation sequence of the epidermal growth factor receptor is fused to the N-terminus of the Luc enzyme. Constructs contain either three (ER-LucT) sites for N-linked glycosylation or a single (ER-LucS) site. B, Mice bearing wild type D54 or C, U87-MG xenograft tumors were randomized into four treatment groups: control, tunicamycin (Tn, 0.75mg/kg), radiation (IR, 5 daily fractions of 2Gy) and the combination of Tn with IR. Data points represent relative tumor growth compared to the tumor volume on Day 0, and error bars report the standard error. (From [36], with permission).