Table 5.
Unadjusted trend analysis: SP a -IPTp b doses (continuous variable) associated with outcomes of interest
| Outcome | Trend prevalence ratio estimate (95% CI c ) | Trend p-value |
|---|---|---|
| Placental infectiond | ||
| All gravidity | 0.87 (0.77-0.99) | 0.03 |
| Paucigravid | 0.84 (0.72-0.97) | 0.02 |
| Multigravid | 0.91 (0.73-1.12) | 0.37 |
| Low birth weight (<2,500 g) | ||
| All gravidity | 0.59 (0.43-0.81) | <0.01 |
| Paucigravid | 0.50 (0.29-0.85) | 0.01 |
| Multigravid | 0.62 (0.42-0.90) | 0.01 |
| Preterm (<37 weeks) | ||
| All gravidity | 0.65 (0.51-0.81) | <0.01 |
| Paucigravid | 0.82 (0.60-1.12) | 0.21 |
| Multigravid | 0.47 (0.33-0.66) | <0.01 |
| Small for gestational age | ||
| All gravidity | 0.93 (0.75-1.15) | 0.49 |
| Paucigravid | 0.99 (0.74-1.32) | 0.94 |
| Multigravid | 0.85 (0.62-1.17) | 0.32 |
| Composite birth outcomee | ||
| All gravidity | 0.80 (0.70-0.92) | <0.01 |
| Paucigravid | 0.92 (0.76-1.11) | 0.37 |
| Multigravid | 0.67 (0.54-0.84) | <0.01 |
| Anemia (Hb <11 g/dl) | ||
| All gravidity | 0.93 (0.82-1.05) | 0.24 |
| Paucigravid | 0.84 (0.72-0.99) | 0.04 |
| Multigravid | 1.03 (0.86-1.23) | 0.74 |
| Any infectionf | ||
| All gravidity | 0.87 (0.77-0.98) | 0.03 |
| Paucigravid | 0.84 (0.72-0.96) | 0.01 |
| Multigravid | 0.91 (0.74-1.12) | 0.38 |
aSP = sulphadoxine pyrimethamine.
bIPTp = intermittent preventive treatment for malaria in pregnancy.
cCI = 95% confidence interval.
dPlacental infection outcome: histopathology classes 1–4 vs class 5.
eComposite birth outcome defined as infants born with any of: LBW, SGA, or preterm.
fAny infection defined as pathology classes 1–4, blood smear positive (maternal, placental or cord blood).