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. 2015 Feb 8;12:16. doi: 10.1186/s12985-015-0248-x

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© Raut et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Mode of inhibition of DENV-2 NS2b-NS3Pro by MB21. (A) Enzymatic activity of DENV-2 NS2b-NS3Pro as a function of substrate concentration in the absence (filled circles) and presence of 6 μM MB21 (empty circles). The table shows kinetic parameters in presence (E + S + I) and absence (E + S) of MB21. E, S and I denote the enzyme, DENV-2 NS2b-NS3Pro, the substrate, Bz-nKRR-AMC, and the inhibitor, MB21. (B) Lineweaver-Burke plot of DENV-2 NS2b-NS3Pro activity in the absence (filled circles) and presence of 6 μM MB21 (empty circles). Data were analyzed using GraphPad Prism software.