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. Author manuscript; available in PMC: 2015 Feb 13.
Published in final edited form as: Annu Rev Neurosci. 2012 Apr 5;35:417–443. doi: 10.1146/annurev-neuro-060909-153138

Figure 2.

Figure 2

Functional domains of FMRP. Human FMRP, a 632 amino acid polypeptide (gray bar), has a nuclear localization signal (NLS; light blue), two K-homology domains (KH1 and KH2; orange), an RGG (arginine-glycine-glycine) box (dark blue), and a nuclear export sequence (NES; red). R138Q and I304N are naturally occurring mutations in patients with developmental delay and a severe form of FX, respectively. I304N abolishes polyribosome association. S500 is a major site of phosphorylation. Abbreviations: N, amino terminus; C, carboxy terminus; FMRP, fragile x mental retardation protein.