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. Author manuscript; available in PMC: 2015 Mar 18.
Published in final edited form as: Nat Commun. 2014 Mar 18;5:3494. doi: 10.1038/ncomms4494

Figure 7. Apoptosis-resistant BM does not improve survival or crypt regeneration in radiosensitive hosts.

Figure 7

(a) The Kaplan–Meier survival curve of non-transplanted WT, PUMA KO and p21 KO mice exposed to 15 Gy ABI. (b) p21 KO or PUMA KO BMT p21 KO recipients. The Kaplan–Meier survival curve of the BMT mice exposed to 13.5 Gy ABI. (c) H&E staining of intestinal sections from p21 KO BMT mice at the indicated times after exposure to 15 Gy TBI. (× 100 magnification). Scale bar, 100 μm. (d) Quantification of regenerated crypts in BMT mice treated as in c. a and b were analysed by log-rank test. Values in d represent means + s.d. for n = 3 mice per group.