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. Author manuscript; available in PMC: 2015 Oct 10.
Published in final edited form as: J Control Release. 2014 Jul 10;191:15–23. doi: 10.1016/j.jconrel.2014.07.003

Figure 5. L4F-A192 nanoparticles inhibit activation of hepatic stellate cells (HSCs).

Figure 5

Murine HSCs were seeded on plastic for 3 days then stained for α-smooth muscle actin. A) Without treatment, HSC seeded on plastic lose their compact morphology and cytoplasmic lipid droplets and stain positively for α-smooth muscle actin[3]. B) 10 μM A192 added to the media resulted in minimal inhibition of HSCs activation C) 10 μM L4F-A192 treated HSCs exhibit characteristic compact morphology for quiescent stellate cells. Scale bar = 20 μM. D) The fluorescence intensity of α-smooth muscle actin was quantified and compared between HSCs treated with A192 and L4F-A192. *p<0.05; **p<0.01. Values represent the mean ± 95% CI.