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Pharmacokinetics of L4F-A192 and L4F in rats
| * Parameter | Units | L4F-A192 (n=3) | Free L4F (n=3) | ** Significance | ||
|---|---|---|---|---|---|---|
| Average | SD | Average | SD | (p-value) | ||
| Volume of distribution, V0 | mL | 26 | (4) | 12 | (2) | Yes (p=0.02) |
| Plasma half-life, thalf | min | 62 | (36) | 70 | (22) | No (p=0.77) |
| Plasma clearance, CLp | mL min−1 | 0.37 | (0.20) | 0.12 | (0.02) | No (p=0.16) |
Rat body weights were an average of 281 g.
Parameters compared by a two-tailed t test.
