Figure 2. Concentration-dependent effects of BK on PGI2 (6-keto-PGF1α) production in VSMC.
Serum starved VSMC were stimulated with BK (10−10–10−6 M) for 10 min., and the release of 6-keto-PGF1α into the media was measured by RIA. BK produced a concentration dependent increase in 6-keto-PGF1α with a peak response at 10−8M. The figure is representative of 8 separate experiments. *P<0.05 vs. basal.