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. Author manuscript; available in PMC: 2015 Feb 14.
Published in final edited form as: J Recept Signal Transduct Res. 2010 Apr;30(2):61–71. doi: 10.3109/10799890903563768

Figure 9. Scheme depicting BK receptor and IGF-1 receptor signaling through MAPK-dependent pathways.

Figure 9

Activation of src-family of tyrosine kinases result in the activation of MAPK which in turn stimulates the activity of cPLA2. Once activated, cPLA2 in turn will activate cyclooxygenases (COX) resulting in the production of inhibitory prostaglandins such as PGI2. PGI2 in turn will lead to elevated cAMP levels, and consequent attenuation of the responses of BK and IGF-1 to stimulate matrix proteins.