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. Author manuscript; available in PMC: 2016 Jan 21.
Published in final edited form as: Small. 2014 Sep 5;11(3):319–328. doi: 10.1002/smll.201400765

Scheme 1.

Scheme 1

Synthetic schemes of acid valve assembly and incorporation of targeting agent. NVMSN denote particles that are modified with nanovalve only, and Tf-NV-MSN are particles that have both transferrin and nanovalve derivatizations.