. Author manuscript; available in PMC: 2016 Jan 10.

Published in final edited form as: Breast Cancer Res Treat. 2015 Jan 10;149(2):517–523. doi: 10.1007/s10549-014-3175-4

Table 2.

Association of polygenic risk score (PRS) and breast cancer (n = 592 cases, 1,171 controls) within the National Surgical Adjuvant Breast and Bowel Project P-1 and P-2 trials

	Cases	Controls	Odds ratio (95 % CI)	P value^*
PRS quintiles
Q1 (<5.17)	95 (16.0 %)	258 (22.0 %)	0.81 (0.59–1.12)
Q2 (5.18–5.51)	116 (19.6 %)	236 (20.2 %)	1.07 (0.78–1.47)
Q3 (5.52–5.78)	114 (19.3 %)	239 (20.4 %)	1.00 (ref)
Q4 (5.79–6.10)	125 (21.1 %)	227 (19.4 %)	1.17 (0.85, 1.61)
Q5 (>6.10)	142 (24.0 %)	211 (18.0 %)	1.45 (1.06, 1.98)	0.0005

P value for trend