Table 1.
Patient characteristics, local therapy, and outcome
| Pt # | Age at diagnosis (m) | Gender | Protocol | Stage | Surgery | Age at RT (m) | Site of PD before RT | Primary site RT (GyRBE) | CSI (GyRBE) | All planned RT given | Site of PD after RT | Vital status | OS from diagnosis (m) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 | F | DFCI02-294 | M1 | GTR | 6 | 9 | No | Dead | 3 | |||
| 2 | 6 | M | DFCI02-294 | M2 | GTR | 9 | 32.4 | No | brain | Dead | 5 | ||
| 3 | 7 | M | DFCI02-294 | M4* | STR | 10 | spine | 45 | Yes | Dead | 5 | ||
| 4 | 8 | F | ACNS0333 | M0 | Biopsy | 19 | brain | 21.6 | No | brain, spine | Dead | 14 | |
| 5 | 8 | M | ACNS0333 | M0 | GTR | 11 | 50.4 | Yes | spine | Alive | 27 | ||
| 6 | 8 | M | DFCI02-294 | M0 | STR | 12 | 54 | Yes | brain | Dead | 13 | ||
| 7 | 12 | F | ACNS0333 | M0 | STR | 15 | 50.4 | Yes | Alive | 24 | |||
| 8 | 13 | F | EU-RHAB | M0 | GTR | 20 | 52.2 | Yes | Alive | 28 | |||
| 9 | 14 | F | ACNS0333 | M3 | GTR | 20 | 45 | 23.4 | Yes | Alive | 17 | ||
| 10 | 15 | F | EU-RHAB | M0 | GTR | 21 | 54 | Yes | Alive | 7 | |||
| 11 | 16 | M | DFCI02-294 | M2 | STR | 31 | brain | 50.4 | 30.6 | Yes | Dead | 30 | |
| 12 | 16 | F | ACNS0333 | M0 | STR | 19 | 50.4 | Yes | Dead | 25 | |||
| 13 | 17 | F | ACNS0333 | M0 | GTR | 19 | 50.4 | Yes | Alive | 48 | |||
| 14 | 18 | M | DFCI02-294 | M0 | GTR | 20 | 54 | Yes | Alive | 48 | |||
| 15 | 18 | F | None | M2 | STR | 21 | 50.4 | Yes | brain | Dead | 5 | ||
| 16 | 19 | M | ACNS0333 | M0 | GTR | 21 | 50.4 | Yes | Alive | 37 | |||
| 17 | 20 | M | None | M3 | STR | 24 | 45 | Yes | CSF | Dead | 27 | ||
| 18 | 25 | F | DFCI02-294 | M0 | STR | 27 | brain | 52.2 | Yes | Alive | 16 | ||
| 19 | 25 | F | EU-RHAB | M2 | STR | 33 | 54 | Yes | Alive | 39 | |||
| 20 | 35 | M | SJMB03 | M3 | Biopsy | 36 | 54 | 36 | Yes | Alive | 11 | ||
| 21 | 35 | F | EU-RHAB | M3 | STR | 45 | 51 | 24 | Yes | Alive | 13 | ||
| 22 | 36 | F | ACNS0333 | M1 | GTR | 42 | 54 | 36 | Yes | Alive | 24 | ||
| 23 | 41 | F | SJMB03 | M0 | GTR | 44 | 54 | 23.4 | Yes | Dead | 21 | ||
| 24 | 41 | M | DFCI02-294 | M3 | STR | 44 | 54 | 36 | Yes | Alive | 53 | ||
| 25 | 43 | M | SJMB03 | M0 | GTR | 45 | 55.8 | 23.4 | Yes | Dead | 7 | ||
| 26 | 46 | F | None | M1 | Biopsy | 49 | 54 | 30.6 | Yes | brain, spine | Dead | 22 | |
| 27 | 48 | F | None | M0 | GTR | 49 | 54 | 30.6 | Yes | Alive | 41 | ||
| 28 | 51 | F | ACNS0333 | M3 | STR | 57 | brain, spine | 43.2 | 36 | No | Alive | 22 | |
| 29 | 55 | M | SJMB03 | M0 | GTR | 58 | 55.8 | 23.4 | Yes | brain | Dead | 35 | |
| 30 | 55 | M | ACNS0333 | M2 | STR | 62 | 54 | 23.4 | Yes | Alive | 40 | ||
| 31 | 55 | F | SJMB03 | M0 | GTR | 57 | 55.8 | 23.4 | Yes | Alive | 26 |
*
Patient had positive CSF, brain metastases, spine metastases, and kidney lesion.
Pt, Patient; m, months; RT, radiation therapy; PD, progressive disease; CSI, craniospinal irradiation; GyRBE, cobalt-Gray equivalent; F, female; M, male; DFCI, Dana-Farber Cancer Institute; GFR, gross total resection; STR, subtotal resection; RT, radiation therapy; OS, overall survival