Table 2.
Toxicities during radiation.
| Pt # | Primary site RT (GyRBE) | CSI (GyRBE) | Concurrent chemo | Toxicity during RT* |
|---|---|---|---|---|
| 1 | 9 | VCR, triple IT | Death due to sepsis (5) | |
| 2 | 32.4 | Etoposide | ||
| 3 | 45 | CYC, etoposide, VCR, triple IT | Neutropenia (3) | |
| 4 | 21.6 | |||
| 5 | 50.4 | |||
| 6 | 54 | CDDP, CYC, etoposide | ||
| 7 | 50.4 | |||
| 8 | 52.2 | |||
| 9 | 45 | 23.4 | ||
| 10 | 54 | Etoposide | ||
| 11 | 50.4 | 30.6 | Bevacizumab, irinotecan | Sepsis (4), emesis (3) |
| 12 | 50.4 | |||
| 13 | 50.4 | |||
| 14 | 54 | CDDP, CYC, etoposide | ||
| 15 | 50.4 | IT depocyt, carbo | ||
| 16 | 50.4 | |||
| 17 | 45 | Carbo, IT MTX | ||
| 18 | 52.2 | |||
| 19 | 54 | |||
| 20 | 54 | 36 | Neutropenia (3) | |
| 21 | 51 | 24 | Etoposide | |
| 22 | 54 | 36 | Pancytopenia (3) | |
| 23 | 54 | 23.4 | ||
| 24 | 54 | 36 | Pancytopenia (4) | |
| 25 | 55.8 | 23.4 | ||
| 26 | 54 | 30.6 | Triple IT, ICE | Pancytopenia (4) |
| 27 | 54 | 30.6 | ||
| 28 | 43.2 | 36 | Thrombocytopenia (4), hypertension (4) | |
| 29 | 55.8 | 23.4 | ||
| 30 | 54 | 23.4 | Vononistat, accutane | Anemia (3) |
| 31 | 55.8 | 23.4 |
*
Grade 3 – 5 per RTOG Acute Radiation Morbidity Scoring Criteria. Grade of each toxicity shown in parentheses.
Pt, Patient; RT, radiation therapy; GyRBE, cobalt-Gray equivalent; VCR, vincristine; CDDP, cisplatin; CYC, cyclophosphamide; MTX, methotrexate; ICE, ifosfamide, carbo, etoposide; IT, intrathecal; carbo, carboplatin