Table 3.
Pt # | Age at RT (m) | Surgery | Chemo before RT | Chemo with RT | Location of tumor bed | Location of imaging changes | Time to imaging changes after RT end (m) | Clinical signs concerning for RT reaction* | Brainstem dose (GyRBE) |
|
---|---|---|---|---|---|---|---|---|---|---|
Mean | Max | |||||||||
5 | 11 | GTR | Yes | No | PF | Pons, medulla | 4 | Ataxia (3), hypotonia (3) | 52.0 | 55.5 |
7 | 15 | STR | Yes | No | PF | Brainstem, bilateral thalami, cerebellum | 4 | Ataxia (2) | 47.2 | 53.2 |
12 | 19 | STR | Yes | No | Left hemisphere | Pons, midbrain, bilateral hemsipheres | 3 | Quadraplegia (3) bulbar palsies (4) | 28.7 | 52.8 |
13 | 19 | GTR | Yes | No | Foramen of Monroe | Basal ganglia, midbrain | 4 | Hemiparesis (3) bulbar palsies (4) | 20.1 | 51.3 |
|22 | 42 | GTR | Yes | No | PF | Pons | 1 | Unknown | 48.5 | 56.4 |
Grade per CTCAE v4.0 shown in parentheses.
Pt, Patient; RT, radiation therapy; PF, posterior fossa; m, months; GTR, gross total resection; STR, subtotal resection