Table 2.
Susceptibility of selected isolates tested in Mueller-Hinton broth (strains with same behavior were excluded; the data are presented in Fig. 1)
| Isolate | Species | β-Lactamase | MIC WO | MIC, BIC [mg/L] | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ceftazidime | Cefepime | Ertapenem | Meropenem | Imipenem | Doripenem | |||||||||
| ATCC25922 | E. coli | – | 0.125 | 0.125 | 0.064 | 0.032 | 0.016 | 0.032 | 0.016 | 0.016 | 0.125 | 0.064 | 0.016 | 0.016 |
| OXA-48-type producers | ||||||||||||||
| OXA_N1 | Citrobacter freundii | OXA-162, SHV-5 | >32 | 2 | 4 | ≤0.5 | 4 | >32 | 0.5 | 4 | 0.5 | ≤0.5 | ≤0.5 | 2 |
| OXA_N2 | Enterobacter cloacae | OXA-48, TEM-1, CTX-M-15 | >32 | 8 | 32 | 4 | >32 | >32 | 32 | >32 | 16 | 8 | 16 | 16 |
| OXA_N3 | E. coli | OXA-162, TEM-1 | 0.5 | ≤0.5 | 1 | ≤0.5 | >32 | >32 | 16 | >32 | 4 | 2 | 8 | 16 |
| OXA_N4 | E. coli | OXA-48, TEM-1, OXA-1 | 4 | 1 | 16 | 4 | >32 | >32 | 32 | >32 | 32 | 8 | 16 | 1 |
| OXA_N5 | E. coli | OXA-48, TEM-1, OXA-1 | 32 | 4 | 32 | 2 | 4 | >32 | 0.5 | 8 | 0.5 | ≤0.5 | ≤0.5 | 1 |
| OXA_N6 | E. coli | OXA-48, TEM-1, OXA-1 | 0.5 | ≤0.5 | 0.5 | ≤0.5 | 0.5 | 32 | ≤0.5 | 2 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 |
| OXA_C3 | K. pneumoniae | OXA-48, SHV-1 | 4 | 4 | 16 | 1 | 1 | >32 | ≤0.5 | 8 | ≤0.5 | ≤0.5 | ≤0.5 | 1 |
| OXA_N9 | Raoultela ornithinolytica | OXA-162, TEM-1, OXA-1, SHV-5 | >32 | 1 | 2 | ≤0.5 | 4 | >32 | 0.5 | 4 | 0.5 | ≤0.5 | ≤0.5 | 4 |
| Other carbapenemase-producing isolates | ||||||||||||||
| KPC_C1 | K. pneumoniae | KPC-2, OXA-9, TEM-1, SHV-12 | >32 | >32 | 16 | 16 | >32 | >32 | 8 | >32 | 8 | 2 | 4 | 2 |
| KPC_C2 | K. pneumoniae | KPC-3, OXA-9, TEM-1, SHV-12 | >32 | >32 | >32 | 16 | >32 | >32 | >32 | >32 | 8 | 1 | 32 | 32 |
| KPC_C3 | K. pneumoniae | KPC-3, OXA-9, TEM-1, SHV-12 | 8 | 16 | 8 | 1 | 1 | >32 | ≤0.5 | 8 | ≤0.5 | ≤0.5 | ≤0.5 | 8 |
| NDM_B1 | E. coli | NDM-1, TEM-1 | >32 | 16 | >32 | 4 | 16 | 16 | 4 | 4 | 2 | 0.5 | 8 | 32 |
| NDM_B2 | Citrobacter freundii | NDM-1, TEM-1, intrinsic AmpC | 32 | 32 | 16 | 8 | >32 | >32 | 8 | >32 | 4 | 2 | 16 | 2 |
| NDM_B3 | Providencia stuartii | NDM-1, intrinsic AmpC | >32 | >32 | 8 | 8 | 4 | 16 | 4 | 16 | 8 | 16 | 4 | 2 |
| VIM_C1 | K. pneumoniae | VIM-1, SHV-1 | >32 | >32 | >32 | 8 | >32 | >32 | >32 | >32 | 16 | 1 | >32 | >32 |
| VIM_C2 | K. pneumoniae | VIM-1, SHV-1 | >32 | 16 | >32 | 8 | 4 | >32 | 1 | 8 | 1 | ≤0.5 | 2 | 2 |
| VIM_C3 | K. pneumoniae | VIM-1, SHV-1 | >32 | >32 | 32 | 32 | 4 | >32 | 4 | 32 | 2 | 2 | 4 | 16 |
| VIM_C4 | K. pneumoniae | VIM-4, CMY-4 | >32 | >32 | >32 | 16 | >32 | >32 | >32 | 32 | 8 | 2 | >32 | 8 |
| Non-carbapenemase-producing carbapenem resistant isolates | ||||||||||||||
| DHA_C1 | K. pneumoniae | DHA-1, TEM-1, OXA-1 | >32 | 32 | >32 | 16 | >32 | >32 | 2 | 32 | 2 | 8 | 2 | 4 |
| DHA_C2 | K. pneumoniae | DHA-1, TEM-1, OXA-1, SHV-5 | >32 | >32 | >32 | 8 | >32 | >32 | 8 | 16 | 4 | 4 | 4 | 1 |
| DHA_C3 | K. pneumoniae | DHA-1, TEM-1, OXA-1 | >32 | >32 | 2 | 2 | >32 | 16 | 4 | 4 | 1 | ≤0.5 | 2 | 0.5 |
| SHV_C1 | K. pneumoniae | TEM-1, SHV-1, SHV-5 | >32 | 8 | >32 | 16 | >32 | 32 | 4 | 4 | 1 | ≤0.5 | 2 | ≤0.5 |
| SHV_C2 | K. pneumoniae | TEM-1, SHV-1, SHV-5 | >32 | 4 | >32 | 16 | 8 | >32 | 2 | 4 | 2 | 1 | 1 | 0.5 |
| Carbapenem susceptible isolates | ||||||||||||||
| ESBL_P1 | E. coli | TEM-1, OXA-1, CTX-M-15 | 32 | 2 | 16 | 1 | ≤0.5 | 16 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 |
| ESBL_P2 | K. pneumoniae | TEM-1, SHV-1, SHV-5 | 32 | 16 | 4 | ≤0.5 | ≤0.5 | 2 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 |
| ESBL_P3 | K. pneumoniae | TEM-1, SHV-1, SHV-5 | >32 | 8 | 2 | ≤0.5 | ≤0.5 | 4 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 |
| ESBL_P4 | K. pneumoniae | TEM-1, SHV-1, SHV-12 | >32 | 16 | 2 | ≤0.5 | ≤0.5 | 2 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 |
| ESBL_P5 | Providencia stuartii | TEM-92, intrinsic AmpC | 16 | ND | 8 | ND | ≤0.5 | ND | ≤0.5 | ND | ≤0.5 | ND | ≤0.5 | ND |
MIC minimal inhibitory concentration, MIC, WO minimal inhibitory concentration determined without NaHCO3, MIC, BIC MIC determined in presence of 50 mmol/L NaHCO3, ND no growth observed
Significant changes are in bold