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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biomaterials. 2015 Jan 16;0:26–34. doi: 10.1016/j.biomaterials.2014.12.050

Table 2.

Cardiac function with E-domain peptide eluting MRS and empty MRS treatments in mice at 10 wks post-MI. Pressure-volume loop measurements in the closed chest configuration. HR-heart rate (beats per minute), MAP-mean arterial pressure (mmHg), ESP-end-systolic pressure (mmHg), EDP-end-diastolic pressure (mmHg), ESV-end systolic volume (μl), EDV-end diastolic volume (μl), SV-stroke volume (μl), CO-cardiac output (μl/min), CI-cardiac index (μl/min/g), EF-ejection fraction (%), SW-stroke work (mmHg/μl), dP/dtmax-maximum first derivative of change in systolic pressure with respect to time (mmHg/sec), dP/dtmin-maximum first derivative of change in diastolic pressure with respect to time (mmHg/sec), Tau-Glantz-time constant of fall in ventricular pressure by Glantz method (msec), MaxPower-maximum power (mWatts), TPR-total peripheral resistance (mmHg/μl/min).

Group Parameter Sham 10 wk MI MI+Epeptide MRS MI+MRS
HR 510.4±21.3 450±19.8 499.5±22.5 455.6±28
MAP 54±3.4 40.2±3.8* 56±5.5† 49.4±0.9
ESP 76±4.5 56±6 74.4±8.4 72.6±1.5
EDP 4±1.8 2.9±0.6 5.69±1 3±0.75
ESV 33.2±4.2 44.5±10.8 18.8±4.7† 41.9±8.9
EDV 54.2±5 60.2±12.6 38.6±8.2 59.6±11.3
SV 21±1.3 15.6±2 19.8±3.4 17.6±3
CO 10622.6±322.4 7109.6±1106* 9742.2±1606 7714.8±856*
CI 168.8±10.6 152.3±15.4 151±7.8 143.5±12.4
EF 40.4±2.8 27.9±2.3* 52.5±3.3*† 31±3.4*
SW 1777.9±146.2 924.9±222.2* 1670.8±211.7 1243.3±309.5
dP/dtmax 5350.5±462.2 3036.5±251.3* 5598.5±895.6† 3806±158
dP/dtmin -5331.7±428.7 -3028.6±365.6* -5484.4±847.8† -4211.7±167.6
Tau-G 10.3±1.3 17.2±2.4* 9.8±1.4† 13.4±1
MaxPower 294508.5±43464.8 117937.8±17734* 337792.7±82960† 169582.2±8421
TPR 5.1±0.4 6±0.65 6.2±1.2 6.7±0.65
*

P<0.05 vs. Sham,

†

P<0.05 vs. 10 wk MI (n=5-6 per group).