Table 1.
Results for 17 previously published melanoma susceptibility regions
| SNP first reported by the reference study |
Most significant SNP in this study |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Chromosome | Gene | Reference study | SNP name | Position | p value | R2 for melanoma risk | SNP name | Position | p value | R2 for melanoma risk |
| 1q21.3 | ARNT | MacGregor et al.8 | rs7412746 | 150860471 | 2.6 × 10−4 | 0.08 | rs3768013 | 150815411 | 2.9 × 10−6 | 0.13 |
| 1q42.12 | PARP1 | MacGregor et al.8 | rs3219090 | 226564691 | 6.4 × 10−6 | 0.12 | rs1858550 | 226608104 | 1.7 × 10−7 | 0.16 |
| 2q33-q34 | CASP8 | Barrett et al.4 | rs13016963 | 202162811 | 9.5 × 10−7 | 0.14 | rs2349073 | 202186986 | 6.3 × 10−8 | 0.17 |
| 5p15.33 | TERT | Rafnar et al.17 | rs401681 | 1322087 | 4.9 × 10−11 | 0.25 | rs2447853 | 1333077 | 5.7 × 10−12 | 0.27 |
| 5p13.2 | SLC45A2 | Guedj.18 | rs16891982 | 33951693 | 2.2 × 10−9 | 0.20 | as reference | |||
| 6p25-p23 | IRF4 | Duffy et al.19 | rs12203592 | 396321 | 0.014 | 0.04 | rs9405705 | 470384 | 1.5 × 10−4 | 0.08 |
| 9p21 | CDKN2A | Bishop et al.5 | rs7023329 | 21816528 | 8.3 × 10−14 | 0.32 | rs869330 | 21804617 | 3.8 × 10−16 | 0.38 |
| 9p23 | TYRP1 | Duffy et al.20 | rs2733832 | 12704725 | 0.43 | 0.01 | rs72706189 | 11877260 | 1.3 × 10−5 | 0.11 |
| 11q13 | CCND1 | Barrett et al.4 | rs1485993 | 69362414 | 4.5 × 10−9 | 0.20 | rs12422135 | 69378260 | 3.5 × 10−10 | 0.22 |
| 11q14-q21 | TYR | Bishop et al.5 | rs1393350 | 89011046 | 5.3 × 10−13 | 0.30 | rs1126809 | 89017961 | 9.8 × 10−15 | 0.34 |
| 11q22-q23 | ATM | Barrett et al.4 | rs1801516 | 108175462 | 1.8 × 10−7 | 0.16 | rs4753835 | 108145249 | 1.7 × 10−7 | 0.16 |
| 15q13.1 | OCA2 | Amos et al.3 | rs1129038 | 28356859 | 0.081 | 0.02 | rs145720174 | 28468231 | 4.8 × 10−4 | 0.07 |
| 16q12.2 | FTO | Iles et al.21 | rs12596638 | 54115829 | 5.1 × 10−7 | 0.14 | as reference | |||
| 16q24.3 | MC1R | Bishop et al.5 | rs258322 | 89755903 | 6.8 × 10−41 | 1.02 | rs73283859 | 90062520 | 3.6 × 10−52 | 1.31 |
| 20q11.2-q12 | ASIP | Bishop et al.5 | rs2284378 | 32818707 | 1.4 × 10−6 | 0.13 | rs6059655 | 32665748 | 2.1 × 10−11 | 0.26 |
| 21q22.3 | MX2 | Barrett et al.4 | rs45430 | 42746081 | 2.9 × 10−8 | 0.18 | rs443099 | 42743327 | 1.1 × 10−8 | 0.19 |
| 22q13.1 | PLA2G6 | Bishop et al.5 | rs6001027 | 38545619 | 3.8 × 10−7 | 0.15 | rs3891103 | 38537159 | 2.9 × 10−9 | 0.20 |
Trend test p values for association in this study for the SNP reported by the reference study and for the SNP with the strongest signal in this study. The R2 for percentage of variation explained in melanoma risk is also given from the study. The gene listed is the gene considered to be the likely candidate in the region. Positions are build 37.