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. 2015 Jan 28;230(5):1024–1032. doi: 10.1002/jcp.24830

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© 2014 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Upregulation of MHCII+ microgia cells in the SN and CP in chronic TBI rats. Quantification of MHCII immunostaining reflects mean estimated volume of MHCII+ activated microglia cells in the SN and CP in the contralateral and ipsilateral side (A, B). SN, F_3,2 = 7.951; P < 0.001; CP, F_3,2 = 16.18; P < 0.0001. Arrows indicate MHCII+ activated microglia cells ipsilateral SN and CP from TBI injury. Photomicrographs correspond to representative SN in coronal sections immunostained with MHCII/OX6 antibody. (C) Top part left: SN, sham control (contralateral, ipsilateral, and magnification); top part right: SN, TBI (contralateral, ipsilateral, and magnification); bottom part left: CP, sham control (contralateral, ipsilateral, and magnification); bottom part right: CP, TBI (contralateral, ipsilateral, and magnification); scale bar = 100 μm, magnification = 1 μm. Significance at P's < 0.05.