Table 1.
Frequency of identified single‐nucleotide polymorphisms in colorectal cancer, and their effect sizes (from Tenesa and Dunlop7)
| Gene/locus | Chromosome | SNP | Effect size (odds ratio) | Allele frequency | Population attributable risk (%) |
|---|---|---|---|---|---|
| – | 8q24 | rs6983267 | 1·21 (1·15, 1·27) | 0·51 | 9·7 |
| GREM1 | 15q13 | rs4779584 | 1·26 (1·19, 1·34) | 0·18 | 4·5 |
| SMAD7 | 18q21 | rs4939827 | 1·18 (1·12, 1·23) | 0·52 | 8·6 |
| – | 11q23 | rs3802842 | 1·12 (1·07, 1·17) | 0·29 | 3·4 |
| EIF3H | 8q23 | rs16892766 | 1·25 (1·19, 1·32) | 0·07 | 1·7 |
| — | 10p14 | rs10795668 | 1·12 (1·10, 1·16) | 0·67 | 7·4 |
| BMP4 | 14q21 | rs4444235 | 1·11 (1·08, 1·15) | 0·46 | 4·8 |
| CDH1 | 16q22 | rs9929218 | 1·10 (1·06, 1·12) | 0·71 | 6·6 |
| RHPN2 | 19q13 | rs10411210 | 1·15 (1·10, 1·20) | 0·90 | 11·9 |
| BMP2 | 20q12 | rs961253 | 1·12 (1·08, 1·16) | 0·35 | 4·0 |
Values in parentheses are 95 per cent c.i. SNP, single‐nucleotide polymorphism.