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. 2015 Jan 24;12(1):2. doi: 10.1186/2045-8118-12-2

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© Silverberg et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Sections of sham-operated and kaolin-injected rats 10 weeks after injection. Comparison of a representative sham-operated tgAPP21 rat (left panels) to a representative kaolin-injected tgAPP21rat (right panels) at three different coronal brain levels: the level of the striatum (A & B), the level of the hippocampus (C & D), and the level of the cerebral aqueduct (E & F). Note the marked ventricular and aqueductal enlargement in the kaolin-treated tgAPP21 rat compared to sham-operated rat (arrows). H&E stain, ×10.