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. 2015 Jan 24;12(1):2. doi: 10.1186/2045-8118-12-2

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© Silverberg et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunohistochemical staining for Aβ40. (A) Hippocampal neurons in a sham-operated six-month-old tgAPP21 rat (arrows). There is minimal immunoreactivity evident 10 weeks after sham-surgery, x80. (B) Hippocampal neurons in a hydrocephalic six-month-old tgAPP21 rat 10 weeks after kaolin injection demonstrating enhanced immunoreactivity in areas CA2 and CA3 (arrows), ×80. (C) Frontoparietal cortical neurons (arrow) in a sham-operated six-month-old tgAPP21 rat at 10 weeks post-surgery showing minimal Aβ40 immunoreactivity, ×200. (D) There is more robust neuronal immunoreactivity in the frontoparietal cortex in six-month-old tgAPP21 rats 10 weeks following kaolin injection (arrow), ×200.