Figure 2.

BACE1 is abnormally hyper-modified with bisecting GlcNAc in AD patients

1. Summary of clinical and histological data of non-AD control (NC), early-stage AD (eAD) or AD patients.
2. BACE1 from temporal lobe membrane fractions of NC, eAD, or AD patients was immunoprecipitated and blotted with E4-PHA (upper) or anti-BACE1 (lower). The signal intensity of E4-PHA relative to that of BACE1 was calculated (n = 10). The graph shows means ± SEM (*P < 0.05; one-way ANOVA with post hoc Tukey–Kramer test. P = 0.014 for NC versus eAD, P = 0.028 for NC versus AD).

Source data are available online for this figure.