Figure 7.

Limited impairment of BACE1 activity in Mgat3^−/− brain

1. Membrane fractions from 3-week-old Mgat3^+/+, Mgat3^−/−, and Bace1^−/− mice were immunoblotted for CHL1 (upper), contactin-2 (middle), or syntaxin 6 (lower) (n = 4–5). The graphs show means ± SEM (**P < 0.01; two-way ANOVA with post hoc Tukey–Kramer test, P = 0.006 for Mgat3^+/+ versus Bace1^−/−, P = 0.008 for Mgat3^−/− versus Bace1^−/− in CHL1/syn6, P = 0.001 for Mgat3^+/+ versus Bace1^−/−, P = 0.002 for Mgat3^−/− versus Bace1^−/− in Contactin-2/syn6).
2. Number of pups surviving at 4 weeks following a cross between heterozygous male and female mice.

Source data are available online for this figure.