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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cytokine. 2015 Jan 23;72(1):71–85. doi: 10.1016/j.cyto.2014.11.007

Figure 8. Model for OSM role in chronic inflammation and tumor metastasis.

Figure 8

(A) Inflammatory cells infiltrate into a particular microenvironment and secrete OSM, which binds to ECM and helps to nurture an inflammatory or pro-metastatic microenvironment. (B) Immobilized bioactive OSM maintains a prolonged OSM response ultimately resulting in chronic inflammation or tumor metastasis. A non-OSM secreting, proliferating tumor may also come into contact with immobilized OSM secreted from inflammatory cells. The interaction of immobilized OSM with proliferating tumor cells may induce an EMT in the tumor cells and enhance tumor metastasis.