Figure 2.

Is the coupling between innate and adaptive IA reminiscent of kinetic proofreading? Innate immune activation obligatorily follows SIV/HIV infection. It is not actively attenuated via a distinct signaling event in natural hosts, but sufficiently early to reach a kinetically encoded set-point and thus autoattenuated. AIDS progressors display too late (with respect to peak-viremia) innate IA to ever reach this set-point. Anything beyond IA set-point is without relevance to the system as it can no-longer reach the auto-attenuation signal