Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model illustrating the Ras→SAF-1/MAZ→VEGF signaling network axis. Ras activates SAF-1/MAZ by Raf-MEK-ERK-MAPK pathway of phosphorylation. Activated SAF-1/MAZ promotes Ras expression by transcriptional induction of ras gene. The cyclical feed-forward regulation of SAF-1/MAZ and Ras promotes angiogenesis by promoting VEGF expression 14,27. SAF-1, serum amyloid A activating factor 1; VEGF, vascular endothelial growth factor.
