Table 3.
Comparison of Her2/neu status results (10 individual pathologists) with consensus results from the previous study 14 (panel of three pathologists)
| Number of discordant ratings (10 individual pathologists) | |||||||
|---|---|---|---|---|---|---|---|
| Consensus results from the previous study 14 (panel of three pathologists) | Method 3: virtual microscopy with manual outlining | ||||||
| Case no. | Her2/neu IRS | Her2/neu SISH | Her2/neu Status | Method 1: microscope | Method 2: virtual micropscopy | Visual estimation by pathologists | Computation of outlined areas |
| 1 | 3+ | Positive | Positive | 1 | 2 | 3 | 10 |
| 2 | 3+ | Positive | Positive | 0 | 0 | 0 | 0 |
| 3 | 3+ | Positive | Positive | 0 | 0 | 0 | 0 |
| 4 | 2+ | Negative | Negative | 1 | 0 | 0 | 0 |
| 5 | 3+ | Positive | Positive | 0 | 0 | 0 | 0 |
| 6 | 3+ | Positive | Positive | 1 | 0 | 0 | 0 |
| 7 | 3+ | Positive | Positive | 6 | 6 | 8 | 10 |
| 8 | 0 | Negative | Negative | 0 | 0 | 0 | 0 |
| 9 | 3+ | Positive | Positive | 6 | 3 | 3 | 3 |
| 10 | 3+ | Positive | Positive | 0 | 0 | 0 | 0 |
| 11 | 3+ | Positive | Positive | 3 | 1 | 2 | 4 |
| 12 | 0 | Negative | Negative | 0 | 0 | 0 | 0 |
| Total | 181 (15%) | 12 (10%) | 16 (13.3%) | 27 (22.5%) | |||
Except for one false-positive rating (case no. 4, Method 1), all discordant ratings were false-negative with respect to the consensus Her2/neu status. Total percentages of disagreements refer to the 120 ratings per method that were carried out by the 10 pathologists on the 12 slides.
1
17 false-negative and 1 false-positive rating.