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Effect of oral vismodegib and vehicle administration on body weight and hedgehog signaling in mice. (A) Growth curve for vehicle (open circle, n = 8) and vismodegib (closed circle, n = 8) during 15 weeks of treatment. Value are expressed as means ± SEM. *P < 0.05 versus vehicle-treated group. (B) Two-bottle taste testing for modalities of sweet (600 mmol/L sucrose; top) and bitter taste (50 nmol/L denatonium benzoate, DB, bottom) in vehicle- and vismodegib-treated mice.
