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. Author manuscript; available in PMC: 2016 Feb 13.
Published in final edited form as: Circ Res. 2014 Dec 11;116(4):572–586. doi: 10.1161/CIRCRESAHA.116.305462

TABLE 2.

Data from the CAESAR rabbit model, combined Centers.

Control
Mean ± SD
(n=12)
IPC
Mean ± SD
(n=11)
P value
Exclusions 4/16(=25%) 2/13(=15.4) 0.6804
Number of defibrillations 0.5±1.17 0±0 0.1661
Age (days) 94.08±1.24 93.82±1.4 0.6372
Body weight (kg) 2.23±0.27 2.15±0.19 0.4758
HR (bpm) at Baseline 224.75±22.34 244.64±30.94 0.0965
HR (bpm) at 15’ Occlusion 250.75±22.16 253.18±26.44 0.8144
HR (bpm) at 30’ Occlusion 242.17±23.78 251±33.16 0.4758
HR (bpm) at 45’ Occlusion 237.92±26.14 246.64±24.11 0.4146
HR (bpm) at 15’ Rep. 229.75±27.53 243.27±28.1 0.2576
Heart Weight (g) 7.41±1 7.47±0.76 0.8708
LV Weight (g) 3.42±0.41 3.19±0.4 0.1965
Region at Risk (g) 1.07±0.29 1.04±0.18 0.7595
Infarct (g) 0.49±0.15 0.24±0.08 0.0001
Region at Risk (% of LV) 31.01±5.96 32.56±3.7 0.4592
Infarct (% of RR) 45.54±8.09 23.45±7.75 <0.0001
Infarct (% of LV) 14.11±3.46 7.51±2.28 <0.0001
cTnI (ng/ml) at baseline 0±0 0.02±0.06 0.2946
cTnI (ng/ml) at 1h Rep. 84.96±73.31 21.06±26 0.0134
cTnI (ng/ml) at 2h Rep. 112.69±71.61 36.43±33.57 0.0044
cTnI (ng/ml) at 4h Rep. 88.63±54.89 31.14±16.6 0.0042
cTnI (ng/ml) at 24h Rep. 5.62±5.88 3.06±3.79 0.2267
cTnI (ng/ml) at 48h Rep. 0.64±1.04 0.72±2.05 0.9132
cTnI (ng/ml) cumulative 1360.22±787.08 493.24±251.33 0.0030

IPC – ischemic preconditioning; HR – heart rate; LV – left ventricle/ventricular; RR – region at risk; cTnI – cardiac troponin I.