Table 3.
Summary of MGI Mammalian Phenotype analysis (Enrichr) which identifies abnormal phenotypes associated with mutations in genes of interest. The most statistically significant terms are listed for gene lists with greater H3K4me3 in females (F>M) or males (M>F).1
| Term | # Genes | Adj. p- value2 |
|---|---|---|
| F>M | ||
| seizures | 9 | 0.0047 |
| synaptic transmission | 9 | 0.0266 |
| emotion/affective behavior | 8 | 0.0266 |
| learning/memory/conditioning | 8 | 0.0329 |
| nervous system | 6 | 0.0329 |
| M>F | ||
| embryonic tissue | 11 | 0.0005 |
| nervous system | 11 | 0.0007 |
| eyelid morphology | 5 | 0.0068 |
| embryogenesis development | 7 | 0.0068 |
| embryogenesis phenotype | 7 | 0.0068 |
| brain morphology | 11 | 0.0068 |
1
See Supplementary Table 3 for additional terms and details of this analysis.
2
P-values listed are following adjustment for multiple comparisons.