Table 5.
Adjusted † associations of glucose and triglyceride excursions (of 25 mg/dL) with clinical outcomes (n = 898)
Glucose excursion | Model | Global | Obese (n=375) | Non-obese (n=523) | Interaction ‡ | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | p | ||
Any cardiovascular complication | 1 | 1.15 | (1.06-1.25) | <0.01 | 1.19 | (1.01-1.39) | 0.04 | 1.15 | (1.03-1.27) | 0.01 | 0.86 |
2 | 1.06 | (0.95-1.17) | 0.32 | 1.12 | (0.92-1.36) | 0.26 | 1.03 | (0.89-1.19) | 0.94 | 0.35 | |
Heart disease | 1 | 1.13 | (1.03-1.25) | 0.01 | 1.22 | (1.03-1.46) | 0.02 | 1.10 | (0.98-1.25) | 0.11 | 0.38 |
2 | 1.04 | (0.91-1.18) | 0.57 | 1.20 | (0.96-1.50) | 0.12 | 0.96 | (0.82-1.14) | 0.65 | 0.11 | |
Myocardial infarction | 1 | 1.21 | (1.06-1.38) | <0.01 | 1.32 | (1.03-1.68) | 0.03 | 1.17 | (1.00-1.36) | 0.05 | 0.42 |
Angina | 1 | 1.11 | (0.99-1.25) | 0.09 | 1.21 | (0.99-1.48) | 0.06 | 1.07 | (0.92-1.25) | 0.41 | 0.36 |
Stroke | 1 | 1.23 | (1.02-1.48) | 0.03 | 1.08 | (0.63-1.84) | 0.78 | 1.25 | (1.-1.47) | 0.05 | 0.50 |
Heart failure | 1 | 1.15 | (1.00-1.33) | 0.06 | 1.19 | (0.93-1.52) | 0.16 | 1.15 | (0.95-1.38) | 0.15 | 0.90 |
Triglyceride excursion | Global | Obese (n=375) | Non-obese (n=523) | Interaction ‡ | |||||||
OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | p | ||
Any cardiovascular complication | 1 | 1.00 | (0.90-1.12) | 0.94 | 1.11 | (0.91-1.35) | 0.32 | 0.93 | (0.81-1.08) | 0.34 | 0.15 |
2 | 1.01 | (0.90-1.13) | 0.87 | 1.15 | (0.93-1.43) | 0.20 | 0.91 | (0.78-1.06) | 0.21 | 0.06 | |
Heart disease | 1 | 1.02 | (0.89-1.16) | 0.80 | 1.23 | (0.96-1.58) | 0.10 | 0.91 | (0.78-1.07) | 0.24 | 0.04 |
2 | 1.02 | (0.90-1.17) | 0.72 | 1.25 | (0.95-1.63) | 0.11 | 0.91 | (0.77-1.07) | 0.24 | 0.04 | |
Myocardial infarction | 1 | 1.07 | (0.87-1.32) | 0.52 | 1.12 | (0.79-1.59) | 0.53 | 1.05 | (0.80-1.36) | 0.73 | 0.79 |
Angina | 1 | 1.01 | (0.85-1.19) | 0.93 | 1.36 | (1.01-1.83) | 0.04 | 0.86 | (0.72-1.02) | 0.09 | 0.01 |
Stroke | 1 | 0.96 | (0.76-1.21) | 0.75 | 0.89 | (0.64-1.24) | 0.49 | 0.98 | (0.72-1.33) | 0.92 | 0.76 |
Heart failure | 1 | 1.03 | (0.84-1.27) | 0.76 | 1.09 | (0.79-1.49) | 0.60 | 0.97 | (0.75-1.26) | 0.84 | 0.56 |
ELSA-Brasil, 2008–2010.
†Through logistic regression, as follows:
Model 1: age.
Model 2: model 1 + sex, glycated hemoglobin, duration of diabetes, use of insulin.
‡Excursion versus obesity interaction.