Figure 2.

The mRNA expression of the pro-fibrotic molecular markers in livers of mice during Clonorchis sinensis infection. Mice were orally infected with 45 metacercariae of C. sinensis, livers were collected from infected and non-infected mice at indicated time-points and mRNA levels were determined by qPCR (normalized to beta-actin transcript levels). (A) α-SMA; (B) Col1a; (C) Col III. Data were presented as mean ± SEM from 8 C. sinensis-infected mice and 5 normal control mice at each time-point, * = P < 0.05, ** = P < 0.01, *** = P < 0.001 versus control mice.