Table 3.
Univariate and multivariate analysis of Cezanne associated with survival and recurrence in HCC patients
| Variables* | OS | TTR | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| P -value | P -value | HR | 95% CI | P -value | P -value | HR | 95% CI | |
| Gender (Female vs. Male) | NS | NS | NS | NS | ||||
| Age, years (≤50 vs. > 50) | NS | NS | NS | NS | ||||
| AFP (ng/mL) (≤20 vs. > 20) | 0.016 | NS | 0.049 | NS | ||||
| HBsAg (Negative vs. Positive) | NS | NS | NS | NS | ||||
| GGT (U/l) (≤50 vs. > 50) | 0.001 | NS | 0.006 | NS | ||||
| Liver cirrhosis (No vs. Yes) | 0.006 | 0.008 | 2.216 | 1.232-3.985 | 0.012 | 0.017 | 1.865 | 1.115-3.117 |
| Tumor size (cm) (≤5 vs. > 5) | <0.001 | 0.032 | 1.616 | 1.042-2.504 | <0.001 | 0.004 | 1.866 | 1.222-2.849 |
| Tumor number (Single vs. Multiple) | NS | NS | 0.025 | NS | ||||
| Satellite nodule (No vs. Yes) | NS | NS | 0.009 | NS | ||||
| Tumor capsule (No/incomplete vs. Complete) | NS | NS | NS | NS | ||||
| Tumor differentiation (I-II vs. III-IV) | NS | NS | NS | NS | ||||
| Vascular invasion (No vs. Yes) | <0.001 | <0.001 | 2.941 | 1.706-5.072 | <0.001 | <0.001 | 2.471 | 1.475-4.138 |
| Cezanne (Low versus High) | <0.001 | <0.001 | 0.352 | 0.226-0.546 | <0.001 | <0.001 | 0.354 | 0.237-0.528 |
*TNM stage and BCLC stage was combined with several clinical indexes such as tumor size, number and tumor thrombus; we did not enter the TNM stage and BCLC stage into multiple analysis with these indexes to avoid any bias in analysis.
GGT gamma-glutamyltransferase, AFP α-fetoprotein, OS overall survival, TTR time to recurrence, NS not significant, HR hazard ratio, CI confidential interval.