Table 4.
Univariate and multivariate analysis of coindex of Cezanne/AFP associated with survival and recurrence in HCC patients
| Variables | OS | TTR | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| P -value | P -value | HR | 95% CI | P -value | P -value | HR | 95% CI | |
| Gender (Female vs. Male) | NS | NS | NS | NS | ||||
| Age, years (≤50 vs. > 50) | NS | NS | NS | NS | ||||
| HBsAg (Negative vs. Positive) | NS | NS | NS | NS | ||||
| GGT (U/l) (≤50 vs. > 50) | 0.001 | NS | 0.006 | NS | ||||
| Liver cirrhosis (No vs. Yes) | 0.006 | 0.010 | 2.169 | 1.207-3.897 | 0.012 | 0.030 | 1.756 | 1.055-2.923 |
| Tumor size (cm) (≤5 vs. > 5) | <0.001 | 0.037 | 1.589 | 1.027-2.458 | <0.001 | 0.007 | 1.785 | 1.175-2.710 |
| Tumor number (Single vs. Multiple) | NS | NS | 0.025 | NS | ||||
| Satellite nodule (No vs. Yes) | NS | NS | 0.009 | NS | ||||
| Tumor capsule (No/incomplete vs. Complete) | NS | NS | NS | NS | ||||
| Tumor differentiation (I-II vs. III-IV) | NS | NS | NS | NS | ||||
| Vascular invasion (No vs. Yes) | <0.001 | <0.001 | 3.027 | 1.755-5.221 | <0.001 | <0.001 | 2.615 | 1.559-4.386 |
| Coindex of Cezanne/AFP* | <0.001 | <0.001 | 0.475 | 0.348-0.648 | <0.001 | <0.001 | 0.515 | 0.389-0.681 |
*Coindex of Cezanne/AFP was combined with Cezanne and AFP, therefore, we did not enter the Cezanne and AFP into univariate and multiple analysis with these indexes to avoid any bias in analysis.