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Prostate carcinoma from carrier #4 who had a pathogenic germline mutation in MSH2 (MSH2 del × 1–8). a Hematoxylin and eosin stained sections showing Gleason 8 adenocarcinoma with tumor infiltrating lymphocytes; b and c Immunohistochemistry showing normal nuclear expression of MLH1 in tumor cells (b) and loss of nuclear expression of MSH2 in tumor cells (c). All images magnification ×400
