Table 1.
Demographic variables and genotype frequencies
| Demographic variables (N=138) |
Depressed (N = 79) | Non-depressed (N = 59) | Test statistic | P value | ||
|---|---|---|---|---|---|---|
| Means or Ns |
SDs | Means or Ns | SDs | |||
| Age, years | 69.6 | 6.7 | 69.7 | 5.8 | T136 = 0.05 | 0.9611 |
| Sex | χ2 = 4.08, 1 df | 0.0433 | ||||
| Female | 52 | - | 48 | - | ||
| Male | 27 | - | 11 | - | ||
| Education, years | 14.5 | 2.1 | 15.7 | 1.6 | T134 = 4.08 | 0.0004 |
| History of cardiac complaint | χ2 = 0.2, 1 df | 0.6517 | ||||
| Yes | 14 | - | 9 | - | ||
| No | 63 | - | 50 | - | ||
| History of hypertension | χ2 = 5.82, 1 df | 0.0158 | ||||
| Yes | 29 | 11 | ||||
| No | 48 | 48 | ||||
| Mini-mental state exam | 28.8 | 1.3 | 29.1 | 1.1 | T132 = 1.35 | 0.1808 |
| Baseline right hippocampal volume, ml | 3.08 | 0.39 | 3.13 | 0.42 | T136= 0.85 | 0.3968 |
| Baseline left hippocampal volume, ml | 2.97 | 0.4 | 3.00 | 0.45 | T136 = 0.47 | 0.6395 |
| Cerebrum, ml | 1164.8 | 128.3 | 1140.6 | 117.2 | T136 = 1.12 | 0.2645 |
| rs2638363 (A/G) | χ2 = 2.39, 1 df | 0.1220 | ||||
| GG | 58 | - | 36 | - | ||
| AA/AG | 21 | - | 23 | - | ||
| rs1492103 (C/T) | χ2 = 0.87, 1 df | 0.3522 | ||||
| TT | 58 | - | 39 | - | ||
| CC/CT | 21 | - | 20 | - | ||
| rs12721331 (C/T) | χ2 = 1.43, 1 df | 0.2312 | ||||
| TT | 70 | - | 48 | - | ||
| CC/CT | 9 | - | 11 | - | ||
| rs2675511 (A/G) | χ2 = 1.03, 1 df | 0.3107 | ||||
| AA | 40 | - | 35 | - | ||
| GG/GA | 39 | - | 24 | - | ||
| APOE | χ2 = 0.46, 1 df | 0.4994 | ||||
| APOE4 carriers | 20 | - | 18 | - | ||
| No APOE4 | 59 | - | 41 | - | ||
Continuous variables are presented as means and standard deviations (SDs). Categorical variables are presented as Ns. All continuous variables had equal variances and were tested with pooled T-test, except for education which exhibited unequal variances between the two diagnostic groups and were thus tested using Satterthwaite T-test. Reported P values are two-tailed.
Abbreviations: SD, standard deviation; MMSE, mini-mental state exam