Table 2.
Longitudinal effects of AGTR1 SNPs on hippocampal volumes
| Right hippocampal volume | Left hippocampal volume | |||
|---|---|---|---|---|
| F value | P value | F value | P value | |
| rs2638363 | 5.96 | 0.0160 | 0.81 | 0.3693 |
| rs2638363 by time | 6.43 | 0.0124 | 0.11 | 0.7400 |
| rs2638363 by APOE by time | 4.80 | 0.0303 | 0.14 | 0.7115 |
| rs1492103 | 5.01 | 0.0269 | 0.72 | 0.3967 |
| rs1492103 by time | 5.90 | 0.0166 | 0.10 | 0.7558 |
| rs1492103 by APOE by time | 3.78 | 0.0541 | 0.01 | 0.9100 |
| rs12721331 | 0.20 | 0.6564 | 0.96 | 0.3297 |
| rs12721331 by time | 1.29 | 0.2574 | 0.09 | 0.7709 |
| rs12721331 by APOE by time | 6.45 | 0.0123 | 0.07 | 0.7982 |
| rs2675511 | 4.06 | 0.0459 | 0.30 | 0.5842 |
| rs2675511 by time | 4.62 | 0.0335 | 0.23 | 0.6352 |
| rs2675511 by APOE by time | 0.75 | 0.3890 | 0.3 | 0.5876 |
Analyses conducted using linear mixed effects models. These models tested for the effect of AGTR1 SNP genotype on hippocampal volume and also examined AGTR1 by time and AGTR1 by APOE by time interactions. All models included 138 subjects and controlled for sex, age, diagnostic group (depressed/non-depressed), baseline hippocampal volume, and total cerebral volume. Values in bold denote statistically significant parameters, defined as P < 0.05. Reported P values are two-tailed.